The medications Calibrate clinicians prescribe in our Metabolic Reset are called GLP-1s (glucagon-like peptide-1s). Calibrate clinicians prescribe a variety of GLP-1s, including semaglutide, liraglutide, tirzepatide, and dulaglutide. These GLP-1s are often referred to by their brand name, so you may have heard of these medications as Wegovy®, Ozempic®, Mounjaro®, or Zepbound®, to name a few.

All GLP-1s are clinically-tested, stimulant-free, and non-habit forming. GLP-1s address the underlying biology that is most important for weight loss, and help lower your set point, or the weight your body fights to stay at. GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption.

Regardless of which medication you’re prescribed, our commitment to all of our members remains the same—10% weight loss or you're eligible for money back (see terms).

You can read more about GLP-1s here.

Calibrate is available to associates and their dependents for whom the following apply:

• At least 18 years of age
• Are enrolled in the Company group health plan
• BMI that’s greater than 30 (or greater than 27 with other metabolic conditions such as pre-diabetes, high cholesterol, high blood pressure, cardiovascular disease, non-alcoholic fatty liver disease, obstructive sleep apnea or PCOS)
• Not pregnant, breastfeeding, or planning to become pregnant in the next two years
• Do not have an active substance abuse problem, diabetes, an active eating disorder (e.g., anorexia, bulimia, or binge eating), cancer, recent bariatric surgery (within the past 18 months), active gallbladder disease, a history of pancreatitis in the past six months, or a history of medullary thyroid cancer (MEN syndrome)
• Live in the United States

During your Metabolic Reset, you’ll meet with your accountability coach for 15 minutes, and you’ll spend time completing lessons as part of the Calibrate curriculum to support you throughout your journey.

GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. Not only are they safe, but research shows that they are the most effective medications for sustainable weight loss, especially when combined with lifestyle changes like on Calibrate. GLP-1s are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.

The FDA-approved medications that are a part of the Metabolic Reset are called GLP-1s, and are clinically-tested, stimulant-free, and non-habit forming. Side effects are extremely rare, and most individuals who take a GLP-1 do not experience any. For those who do, nausea is the most common, and this typically resolves over the first few weeks of being on the medication. If you do experience any side effects, you’ll be able to reach out to your Clinical Team directly for support.

In the most recent clinical trials, less than 5% of people discontinued GLP-1 medications because of side effects.