The medications Calibrate clinicians prescribe in our Metabolic Reset are called GLP-1s (glucagon-like peptide-1s) or the combination medication GIP/GLPs (Glucose-dependent insulinotropic polypeptide). Calibrate clinicians prescribe a variety of GLP-1s, including tirzepatide, semaglutide and dulaglutide. These GLP-1s are often referred to by their brand name, so you may have heard of these medications as Zepbound®, Wegovy®, Ozempic®, Mounjaro®, or Foundayo®, to name a few.
All GLP-1 are clinically-tested, stimulant-free, and non-habit forming. GLP-1s address the underlying biology that is most important for weight loss, and help lower your set point, or the weight your body fights to stay at. GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption.
At Calibrate we have a team of insurance navigation experts to help you access an initial GLP-1 medication prescription that's typically around $25/month or less (after any deductible is met). We’ve helped tens of thousands of members access affordable GLP-1s. However, in the unlikely scenario that there is no path to a low-cost GLP-1 for you,
Although medication is an important aspect of our program, medical experts agree: the combination of GLP-1 medication and lifestyle changes is the most effective approach to sustainable weight loss.
Calibrate is available to associates and their dependents for whom the following apply:
- At least 18 years of age
- Are enrolled in the Company group health plan
- BMI of 30+, or a BMI of 27+ with one or more of the following metabolic conditions: pre-diabetes, high cholesterol, high blood pressure, cardiovascular disease, non-alcoholic fatty liver disease, obstructive sleep apnea or PMOS (formally known as PCOS)
- Not pregnant, breastfeeding, or planning to become pregnant in the next one year
- Do not have an active substance abuse problem, an active eating disorder (e.g., anorexia, bulimia, or binge eating), active cancer treatment with chemotherapy or radiation, cancer, recent bariatric surgery (within the past 18 months), active gallbladder disease, a history of pancreatitis in the past six months, or a personal or family history of medullary thyroid cancer (MEN syndrome)
- Live in the United States
GLP-1s are FDA-approved, clinically-tested, stimulant-free, and non-habit forming. Not only are they safe, but research shows that they are the most effective medications for sustainable weight loss, especially when combined with lifestyle changes like on Calibrate. GLP-1s are generally very well tolerated, with limited side effects. Many individuals don’t have any side effects at all. However, for those who do, nausea is the most common, and this typically resolves over the first few weeks. In the most recent clinical trials, at the highest dose, less than 5% of people discontinued GLP-1 medications because of side effects. With direct access to your Medical Team for help with titrating and managing side effects through secure messaging, we expect even less difficulty with side effects. Your Medical Team is available throughout the program for any questions about medication side effects or other medical concerns.
The FDA-approved medications that are a part of the Metabolic Reset are called GLP-1s, and are clinically-tested, stimulant-free, and non-habit forming. Severe side effects are extremely rare, and most individuals who take a GLP-1 do not experience any or mild ones. For those who do, nausea is the most common, and this typically resolves over the first few weeks of being on the medication. If you do experience any side effects, you’ll be able to reach out to your Clinical Team directly for support.
In the clinical trials , 4-8 % of people discontinued GLP-1 medications because of side effects.