Calibrate Unveils Fourth Annual Results Report

Calibrate’s Metabolic Reset program integrates GLP-1 medications with Intensive Lifestyle Intervention (ILI), personalized coaching, and progress tracking. Over three years of real-world outcomes, members have achieved remarkable results, now showcasing 19% average sustained weight loss at 36 months. Calibrate's impact extends far beyond the scale. At 12 months, members experienced meaningful improvements in key metabolic markers also showcased in the 2025 report.

Additionally, members achieved an average waist circumference reduction of 6.1 inches, with 35% of at-risk members normalizing their waist measurements by the 12-month mark. These outcomes were consistent across both direct-to-consumer and enterprise populations.

“Calibrate’s fourth annual Results Report is a testament to the transformative power of combining data-driven insights with a holistic approach to obesity treatment,” said Rob MacNaughton, CEO of Calibrate. “These results are not just a validation of our Metabolic Reset program—they’re proof that we should challenge our industry to rethink how we approach obesity and chronic disease management. For too long, weight has been treated in isolation, overlooking the complex metabolic, behavioral, and systemic factors at play. Calibrate’s sustained outcomes demonstrate that comprehensive, physician-guided programs can deliver lasting health improvements, setting a new standard for care. This is the future of obesity treatment: scalable, sustainable, and designed to address the root causes of one of the most pressing health issues of our time.”

Despite the ongoing GLP-1 shortages in 2024, Calibrate members continued to achieve sustainable weight loss, even in the absence of consistent medication refills. The Metabolic Reset program’s integrated approach—addressing both behavioral and metabolic factors—demonstrates its superior effectiveness over GLP-1 medications alone, delivering lasting weight loss and comprehensive health improvements.

Calibrate remains committed to its mission of changing the way the world treats weight. By leveraging rigorous data and continuous innovation, they aim to redefine obesity care while making meaningful health improvements accessible to all.

To learn more about Calibrate’s transformative outcomes, access the full 2025 Results Report.