What is Ozempic® 2mg?

Learn all about the new Ozempic® 2mg that's making headlines

Table of Contents

What is Ozempic®?
Can Ozempic® lower my risk for major cardiovascular events?
How does Ozempic® work?
The Calibrate difference: Taking Ozempic® as part of a metabolic reset program
What does Ozempic® cost?
Who is eligible for Ozempic®?
Ozempic® side effects
Ozempic® interactions & warnings
Key Takeaways
Frequently Asked Questions

Calibrate doctors prescribe a variety of GLP-1 medications, including semaglutide, liraglutide, and dulaglutide. Ozempic® (semaglutide) 2mg is a new medication Calibrate could offer.

What's the difference between Ozempic® and Ozempic® 2mg? We dig into this recently FDA-approved medication below.

On March 28, 2022, the U.S. Food and Drug Administration (FDA) approved a new dose of the GLP-1 medication, Ozempic®: Ozempic® 2 mg, a higher dose of the once-weekly dosing of semaglutide subcutaneous injection, will now be available to patients in the U.S. Previously, only doses under 1.0 mg were offered.

The manufacturer of Ozempic®, Denmark-based Novo Nordisk, began working on its 2.0 mg dose of its semaglutide medication shortly after a 2019 clinical trial (the SUSTAIN FORTE trial) was published—a study that found that this increased dose better controlled blood sugar levels than doses of 1.0 mg.

According to a Novo Nordisk press release detailing the trial, “People treated with semaglutide 2 mg achieved a statistically significant and superior reduction in HbA1c at week 40 compared to semaglutide 1 mg dose. In the trial, both doses of semaglutide appeared to have a safe and well-tolerated profile. The most common adverse events were gastrointestinal. Compared to semaglutide 1.0 mg, the gastrointestinal adverse events were similar for semaglutide 2.0 mg.”

The 2 mg dose of Ozempic® was first approved for use in the EU in November 2021. Currently, the 2 mg dose of the medication is approved in the United States, Canada, EU, and Switzerland.

Join thousands of members who have lost at least 10% of their body weight.

Am I Eligible?

Ozempic® (semaglutide) is one of several GLP-1 (glucagon-like peptide-1) medications prescribed by Calibrate doctors to work in conjunction with the Calibrate One Year Metabolic Reset. Others include Wegovy®, Trulicity®, Rybelsus®, and Saxenda®.

Many factors are considered when prescribing a GLP-1. Your Calibrate doctor will take into account your unique needs, health history, and insurance coverage when deciding which GLP-1 medication, at which dosage, is right for you. Ozempic® 2.0 mg will become available to Calibrate members, should their doctor prescribe it, at the same time that it is available to the general public.

Have questions? Talk to your Calibrate doctor orcontact us to learn more.

Ozempic® (semaglutide) is a GLP-1 medication that’s FDA-approved for use in patients with type 2 diabetes. It is also used for the treatment of overweight and obesity and works by mimicking the incretin hormones that your body naturally produces when you eat food.

What are incretin hormones, then? Incretin hormones are gut hormone signals released by the small intestine whenever you consume food. These hormones travel throughout the body, signaling the brain, endocrine system, and gastrointestinal system that food has been consumed and is ready to be metabolized by the body for fuel. This results in a complex cascade of hormones and neurotransmitters that work together to communicate feelings of satiety (or feeling full).

Those with overweight or obesity may experience decreased production of natural incretin hormones—so a GLP-1 medication, like Ozempic®, helps the body make up the difference. Beyond their impact on satiety, GLP-1 medications also help regulate blood sugar levels.

Can Ozempic® lower my risk for major cardiovascular events? Very likely. In addition to improving blood sugar levels and A1C, preliminary data suggests that Ozempic® may lower the risk of major cardiovascular events such as heart attack, stroke, or death, particularly in adults with type 2 diabetes and known heart disease.

Ozempic® is a medication that makes it easier to lose body weight and stick to healthy habits. However, it doesn’t produce weight loss on its own: It must be used in combination with lifestyle changes in order to support overall metabolic health and avoid weight regain.

Calibrate’s One Year Metabolic Reset combines GLP-1 medication with evidence-based lifestyle recommendations—the Four Pillars of Metabolic Health—to help participants maximize their success with Ozempic®. These pillars include:

Food
Sleep
Exercise
Emotional health

Calibrate is a One-Year Metabolic Reset that uses proven methods for long-term results—the latest science, FDA-approved medication, 1:1 doctor visits, a structured curriculum, and accountability coaching on food, exercise, sleep, and emotional health—for weight loss of 10% or more. The Calibrate program was designed, vetted, and approved by a Clinical Advisory Board of world-renowned obesity experts.

When you join Calibrate, you’ll complete a Comprehensive Health Intake, including blood work, that your Calibrate doctor will carefully review before customizing your treatment plan and prescribing your medication. If your Calibrate medical team determines that Ozempic® is the right fit for you, they’ll walk you through all of the details on dosage, how to administer the medication, when to take it, and how it will work alongside your One-Year Metabolic Reset.

Keep in mind that Ozempic® is not the right fit for everyone. Calibrate doctors may prescribe other medications based on your unique needs and health insurance coverage.

Ozempic® 2 mg eligibility

All Calibrate members will be considered for Ozempic® as clinically appropriate and insurance eligible. Those with a history of any of the following conditions should talk to a doctor before starting Ozempic®:

Endocrine tumors in the thyroid, parathyroid, pituitary, pancreas, or adrenal glands
A family history of Multiple Endocrine Neoplasia type 2 (MEN2)
Diabetes-related eye disease or vision problems
Pancreatitis
Active gallbladder disease
Kidney disease
Gastrointestinal issues
Thyroid cancer or if someone in your family had thyroid cancer
Pregnant, breast-feeding, or trying to get pregnant
Heavy alcohol consumption

Ozempic® (semaglutide) is a GLP-1 medication that, as of March 2022, is now approved in a 2.0 mg dose in addition to previously-offered 0.5 mg and 1.0 mg doses

The FDA approved Ozempic® 2.0 mg in part thanks to data from a clinical trial that found that this increased dose better controlled blood sugar levels than the previous maximum dose of 1.0 mg
Ozempic® is one of several GLP-1s prescribed by Calibrate doctors to members of the Calibrate program; the specific medication you are prescribed will depend on your unique health history and insurance coverage

While Ozempic® is indicated for use in patients with type-2 diabetes, its active ingredient, semaglutide, has been proven safe and effective for the treatment of overweight and obesity

Traditional weight loss programs don’t work because sustainable weight loss doesn’t come from yo-yo dieting or calorie counting. It comes from improving your metabolic health. Calibrate’s One-Year Metabolic Reset helps you do just that, through a unique combination of doctor-prescribed medication, 1:1 video coaching, and lifestyle tweaks tailored to you. The result? Improved metabolic health and sustained weight loss.

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Frequently Asked Questions

Calibrate doctors prescribe GLP-1s (glucagon-like peptide-1s) because research shows that, in combination with accountability coaching, they are the most effective and safe long-term medication for weight loss. GLP-1s prescribed through the Calibrate program include semaglutide (including Ozempic®), liraglutide, and dulaglutide.

All Calibrate members will be considered for Ozempic® as clinically appropriate and insurance eligible. We will work with your commercial/employer insurance to help get it covered for $25/month or less.

In general, it is safe to stop taking GLP-1s/combined GLP-1s without a special discontinuation schedule, but it is always important to inform your primary care physician and/or endocrinologist about any changes to your care, including a pause of medicine. If you have a comorbidity such as diabetes, your blood sugar management may need to be adjusted.

Most people won’t experience any significant withdrawal symptoms when discontinuing GLP-1s/combined GLP-1. If you do experience any new symptoms, however, you should reach out to the Calibrate Medical Team in your Calibrate App. Please remember that messaging via the app should not be used for urgent care or medical emergencies.

When you are able to restart your medication, the Medical Team will generally start you back on your same dose if you’ve missed two doses or fewer of a weekly GLP-1/combined GLP-1. If you’ve missed more than two doses or are changing to a new brand of medication, the Medical Team may recommend restarting at a lower dose to avoid any temporary increase in side effects.

Please note that these recommendations are intended only for Calibrate members whose medication has been prescribed by a Calibrate provider.

Your Calibrate doctor will review your required lab work and entire health history and can answer any questions you might have about medication interactions during your initial video doctor visit. GLP-1s (the medications that Calibrate doctors prescribe) can be safely taken with other common prescription medications—including those for blood pressure, thyroid, and diabetes—and have no contraindications with other prescription or over-the-counter medications.

See if you're eligible for Calibrate at apply.joincalibrate.com/metabolicreset

We’re sorry that you had this experience, but we’re optimistic that Calibrate could help. We have a team of insurance navigation experts who have helped tens of thousands of members get low-cost GLP-1 access. The majority of our members have been able to get a GLP-1 covered at $25/month (after any deductible was hit). This is because our Insurance Navigation Team explores all GLP-1 medication options that are clinically appropriate for you, our team uses proprietary tools and data to help get your GLP-1 covered, and we take ownership over communicating with your insurance company for you.

Regardless of your medication access status, we are so confident you’ll succeed on Calibrate that we guarantee results. If you don't lose at least 10% weight loss after 12 consecutive months on the Calibrate program, you'll be eligible for 50% of your money back. Read more about our Results Money Back Promise here.

WHAT IS OZEMPIC® 2MG

Ozempic® 2 mg gets FDA approval in the U.S.

Get Started Today

Will Ozempic® 2 mg dose be available for Calibrate members?

What is Ozempic®?

Ozempic® 2 mg eligibility

Key takeaways

IT’S ABOUT BIOLOGY
NOT WILLPOWER

Frequently Asked Questions

Footnotes

Take the first step today

WHAT IS OZEMPIC® 2MG

Ozempic® 2 mg gets FDA approval in the U.S.

Get Started Today

Will Ozempic® 2 mg dose be available for Calibrate members?

What is Ozempic®?

Ozempic® 2 mg eligibility

Key takeaways

IT’S ABOUT BIOLOGYNOT WILLPOWER

Frequently Asked Questions

Footnotes

Take the first step today

IT’S ABOUT BIOLOGY
NOT WILLPOWER